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The chemical biology of long noncodi...

Jurga, Stefan.

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The chemical biology of long noncoding RNAs

Record Type:	Electronic resources : Monograph/item
Title/Author:	The chemical biology of long noncoding RNAs/ edited by Stefan Jurga, Jan Barciszewski.
other author:	Jurga, Stefan.
Published:	Cham :Springer International Publishing : : 2020.,
Description:	x, 544 p. :ill. (some col.), digital ;24 cm.
[NT 15003449]:	Long Non-Coding RNAs Diversity in Form and Function - from Microbes to Humans -- Evolving Roles of Long Noncoding RNAs -- Biogenesis and Function of the Noncoding Isoform-Type LncRNAs -- Long Non-Coding RNAs in a Single Cell Type: Function and Subcellular Localization -- Long Non-Coding RNAs as Scaffolds for Multiprotein Signalling Complexes -- Landscape of Long Non-Coding RNA Genes, Pseudogenes and Protein Genes in Segmental Duplications in the Critical Human Chromosomal Region 22q11.2 -- Long Non-Coding RNAs and Cancer Cells' Drug Resistance: an Unexpected Connection -- Long Noncoding RNAs as Drivers of Acquired Chemoresistance in Hepatocellular Carcinoma -- Single Cell Analysis May Shed new Lights on the Role of LncRNAs in Chemo-Resistance in Gastrointestinal Cancers -- LncRNAs in the Development, Progression, and Therapy Resistance of Hormone-Dependent Cancer -- Tumorigenesis-Related Long Non-Coding RNAs and their Targeting as Therapeutic Approach in Cancer -- Long Non-Coding RNAs in Non-Small Cell Lung Cancer: State of the Art -- Long Non-Coding RNAs in Cardiovascular Diseases -- Long Non-Coding RNAs in Cardiovascular Development and Diseases -- Long Noncoding RNAs as Players in Breast Tumorigenesis -- Drosophila Models to Study Long Non-Coding RNAs Related to Neurological Disorders -- Regulatory Roles of Long Non-Coding RNAs in Skeletal Muscle Differentiation, Regeneration, and Disorders -- Long Noncoding RNAs in Substance Use Disorders -- The Multifaceted Roles of LncRNAs in Diabetic Complications: a Promising, yet Perplexing Paradigm -- Long Non-Coding RNAs in Diabetes and B-cell Regulation.
Contained By:	Springer Nature eBook
Subject:	Non-coding RNA. -
Online resource:	https://doi.org/10.1007/978-3-030-44743-4
ISBN:	9783030447434

The chemical biology of long noncoding RNAs
The chemical biology of long noncoding RNAs[electronic resource] /edited by Stefan Jurga, Jan Barciszewski. - Cham :Springer International Publishing :2020. - x, 544 p. :ill. (some col.), digital ;24 cm. - RNA technologies,v.112197-9731 ;. - RNA technologies ;v.11..

Long Non-Coding RNAs Diversity in Form and Function - from Microbes to Humans -- Evolving Roles of Long Noncoding RNAs -- Biogenesis and Function of the Noncoding Isoform-Type LncRNAs -- Long Non-Coding RNAs in a Single Cell Type: Function and Subcellular Localization -- Long Non-Coding RNAs as Scaffolds for Multiprotein Signalling Complexes -- Landscape of Long Non-Coding RNA Genes, Pseudogenes and Protein Genes in Segmental Duplications in the Critical Human Chromosomal Region 22q11.2 -- Long Non-Coding RNAs and Cancer Cells' Drug Resistance: an Unexpected Connection -- Long Noncoding RNAs as Drivers of Acquired Chemoresistance in Hepatocellular Carcinoma -- Single Cell Analysis May Shed new Lights on the Role of LncRNAs in Chemo-Resistance in Gastrointestinal Cancers -- LncRNAs in the Development, Progression, and Therapy Resistance of Hormone-Dependent Cancer -- Tumorigenesis-Related Long Non-Coding RNAs and their Targeting as Therapeutic Approach in Cancer -- Long Non-Coding RNAs in Non-Small Cell Lung Cancer: State of the Art -- Long Non-Coding RNAs in Cardiovascular Diseases -- Long Non-Coding RNAs in Cardiovascular Development and Diseases -- Long Noncoding RNAs as Players in Breast Tumorigenesis -- Drosophila Models to Study Long Non-Coding RNAs Related to Neurological Disorders -- Regulatory Roles of Long Non-Coding RNAs in Skeletal Muscle Differentiation, Regeneration, and Disorders -- Long Noncoding RNAs in Substance Use Disorders -- The Multifaceted Roles of LncRNAs in Diabetic Complications: a Promising, yet Perplexing Paradigm -- Long Non-Coding RNAs in Diabetes and B-cell Regulation.

This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs) Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.

ISBN: 9783030447434

Standard No.: 10.1007/978-3-030-44743-4doiSubjects--Topical Terms:

923507
Non-coding RNA.

LC Class. No.: QP623

Dewey Class. No.: 572.88

The chemical biology of long noncoding RNAs
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245 0 4 $a The chemical biology of long noncoding RNAs $h [electronic resource] / $c edited by Stefan Jurga, Jan Barciszewski.
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300 $a x, 544 p. : $b ill. (some col.), digital ; $c 24 cm.
490 1 $a RNA technologies, $x 2197-9731 ; $v v.11
505 0 $a Long Non-Coding RNAs Diversity in Form and Function - from Microbes to Humans -- Evolving Roles of Long Noncoding RNAs -- Biogenesis and Function of the Noncoding Isoform-Type LncRNAs -- Long Non-Coding RNAs in a Single Cell Type: Function and Subcellular Localization -- Long Non-Coding RNAs as Scaffolds for Multiprotein Signalling Complexes -- Landscape of Long Non-Coding RNA Genes, Pseudogenes and Protein Genes in Segmental Duplications in the Critical Human Chromosomal Region 22q11.2 -- Long Non-Coding RNAs and Cancer Cells' Drug Resistance: an Unexpected Connection -- Long Noncoding RNAs as Drivers of Acquired Chemoresistance in Hepatocellular Carcinoma -- Single Cell Analysis May Shed new Lights on the Role of LncRNAs in Chemo-Resistance in Gastrointestinal Cancers -- LncRNAs in the Development, Progression, and Therapy Resistance of Hormone-Dependent Cancer -- Tumorigenesis-Related Long Non-Coding RNAs and their Targeting as Therapeutic Approach in Cancer -- Long Non-Coding RNAs in Non-Small Cell Lung Cancer: State of the Art -- Long Non-Coding RNAs in Cardiovascular Diseases -- Long Non-Coding RNAs in Cardiovascular Development and Diseases -- Long Noncoding RNAs as Players in Breast Tumorigenesis -- Drosophila Models to Study Long Non-Coding RNAs Related to Neurological Disorders -- Regulatory Roles of Long Non-Coding RNAs in Skeletal Muscle Differentiation, Regeneration, and Disorders -- Long Noncoding RNAs in Substance Use Disorders -- The Multifaceted Roles of LncRNAs in Diabetic Complications: a Promising, yet Perplexing Paradigm -- Long Non-Coding RNAs in Diabetes and B-cell Regulation.
520 $a This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs) Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.
650 0 $a Non-coding RNA. $3 923507
650 0 $a Nucleic acids. $3 521784
650 0 $a Biomedical engineering. $3 535387
650 1 4 $a Human Genetics. $3 891169
650 2 4 $a Nucleic Acid Chemistry. $3 1243992
650 2 4 $a Biomedical Engineering/Biotechnology. $3 2162071
700 1 $a Jurga, Stefan. $3 2156191
700 1 $a Barciszewski, Jan. $3 719516
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer Nature eBook
830 0 $a RNA technologies ; $v v.11. $3 3503470
856 4 0 $u https://doi.org/10.1007/978-3-030-44743-4
950 $a Biomedical and Life Sciences (SpringerNature-11642)