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Redox-active therapeutics

Batinic-Haberle, Ines.

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Redox-active therapeutics

Record Type:	Electronic resources : Monograph/item
Title/Author:	Redox-active therapeutics/ edited by Ines Batinic-Haberle, Julio S. Reboucas, Ivan Spasojevic.
other author:	Batinic-Haberle, Ines.
Published:	Cham :Springer International Publishing : : 2016.,
Description:	xxx, 694 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Oxidative stress. -
Online resource:	http://dx.doi.org/10.1007/978-3-319-30705-3
ISBN:	9783319307053

Redox-active therapeutics
Redox-active therapeutics[electronic resource] /edited by Ines Batinic-Haberle, Julio S. Reboucas, Ivan Spasojevic. - Cham :Springer International Publishing :2016. - xxx, 694 p. :ill., digital ;24 cm. - Oxidative stress in applied basic research and clinical practice,2197-7224. - Oxidative stress in applied basic research and clinical practice..

This essential volume comprehensively discusses redox-active therapeutics, focusing particularly on their molecular design, mechanistic, pharmacological and medicinal aspects. The first section of the book describes the basic aspects of the chemistry and biology of redox-active drugs and includes a brief overview of the redox-based pathways involved in cancer (such as the role of mitochondria, hydrogen peroxide and endogenous antioxidative defenses) and the medical aspects of redox-active drugs, assuming little in the way of prior knowledge. The second section encompasses several major classes of redox-active experimental therapeutics, which include porphyrins, salens, nitrones, and other metal-containing (e.g., Mn, Fe, Cu, Zn, Sb) drugs as either single compounds or formulations with nanomaterials and quantum dots. Subsequent sections and chapters describe more specialized aspects of redox-active therapeutics in clinical disorders, such as cancer, cardiovascular diseases, diabetes, central nervous system injuries, neurodegenerative diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head and neck and erectile function) and neglected diseases (e.g., leishmaniasis) Numerous illustrations, tables and figures enhance and complement the text; extensive references to relevant literature are also included. Redox-Active Therapeutics is an invaluable addition to Springer's Oxidative stress in applied basic research and clinical practice series. It is essential reading for researchers, clinicians and graduate students interested in understanding and exploring the Redoxome--the organism redox network--as an emerging frontier in drug design, redox biology and medicine.

ISBN: 9783319307053

Standard No.: 10.1007/978-3-319-30705-3doiSubjects--Topical Terms:

899116
Oxidative stress.

LC Class. No.: RB170

Dewey Class. No.: 616.39

Redox-active therapeutics
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520 $a This essential volume comprehensively discusses redox-active therapeutics, focusing particularly on their molecular design, mechanistic, pharmacological and medicinal aspects. The first section of the book describes the basic aspects of the chemistry and biology of redox-active drugs and includes a brief overview of the redox-based pathways involved in cancer (such as the role of mitochondria, hydrogen peroxide and endogenous antioxidative defenses) and the medical aspects of redox-active drugs, assuming little in the way of prior knowledge. The second section encompasses several major classes of redox-active experimental therapeutics, which include porphyrins, salens, nitrones, and other metal-containing (e.g., Mn, Fe, Cu, Zn, Sb) drugs as either single compounds or formulations with nanomaterials and quantum dots. Subsequent sections and chapters describe more specialized aspects of redox-active therapeutics in clinical disorders, such as cancer, cardiovascular diseases, diabetes, central nervous system injuries, neurodegenerative diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head and neck and erectile function) and neglected diseases (e.g., leishmaniasis) Numerous illustrations, tables and figures enhance and complement the text; extensive references to relevant literature are also included. Redox-Active Therapeutics is an invaluable addition to Springer's Oxidative stress in applied basic research and clinical practice series. It is essential reading for researchers, clinicians and graduate students interested in understanding and exploring the Redoxome--the organism redox network--as an emerging frontier in drug design, redox biology and medicine.
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