東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回上頁

切換: 標籤 | MARC模式 | ISBD

The smoothened receptor in cancer an...

Ruat, Martial.

FindBook

Google Book

Amazon

博客來

The smoothened receptor in cancer and regenerative medicine

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The smoothened receptor in cancer and regenerative medicine/ edited by Martial Ruat.
其他作者:	Ruat, Martial.
出版者:	Cham :Springer International Publishing : : 2015.,
面頁冊數:	vii, 210 p. :ill., digital ;24 cm.
內容註:	Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins -- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators -- Receptor modifications in Hedgehog regulation -- Smoothened, stem cell maintenance and brain diseases -- Medulloblastoma, pediatric brain tumors and Smoothened blockade -- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization -- Implications in stem cell maintenance -- Comparison of the crystal structure of Smoothened to known GPCRs structure.
Contained By:	Springer eBooks
標題:	Regenerative medicine - Methods. -
電子資源:	http://dx.doi.org/10.1007/978-3-319-19755-5
ISBN:	9783319197555 (electronic bk.)

The smoothened receptor in cancer and regenerative medicine
The smoothened receptor in cancer and regenerative medicine[electronic resource] /edited by Martial Ruat. - Cham :Springer International Publishing :2015. - vii, 210 p. :ill., digital ;24 cm. - Topics in medicinal chemistry,161862-2461 ;. - Topics in medicinal chemistry ;8.

Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins -- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators -- Receptor modifications in Hedgehog regulation -- Smoothened, stem cell maintenance and brain diseases -- Medulloblastoma, pediatric brain tumors and Smoothened blockade -- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization -- Implications in stem cell maintenance -- Comparison of the crystal structure of Smoothened to known GPCRs structure.

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series topics in medicinal chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

ISBN: 9783319197555 (electronic bk.)

Standard No.: 10.1007/978-3-319-19755-5doiSubjects--Topical Terms:

2156338
Regenerative medicine
--Methods.

LC Class. No.: RM300

Dewey Class. No.: 615.1

The smoothened receptor in cancer and regenerative medicine
LDR:02767nam a2200325 a 4500 001 2007497
003 DE-He213
005 20160114144800.0
006 m d
007 cr nn 008maaau
008 160219s2015 gw s 0 eng d
020 $a 9783319197555 (electronic bk.)
020 $a 9783319197548 (paper)
024 7 $a 10.1007/978-3-319-19755-5 $2 doi
035 $a 978-3-319-19755-5
040 $a GP $c GP
041 0 $a eng
050 4 $a RM300
072 7 $a PSB $2 bicssc
072 7 $a SCI013020 $2 bisacsh
082 0 4 $a 615.1 $2 23
090 $a RM300 $b .S666 2015
245 0 4 $a The smoothened receptor in cancer and regenerative medicine $h [electronic resource] / $c edited by Martial Ruat.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2015.
300 $a vii, 210 p. : $b ill., digital ; $c 24 cm.
490 1 $a Topics in medicinal chemistry, $x 1862-2461 ; $v 16
505 0 $a Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins -- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators -- Receptor modifications in Hedgehog regulation -- Smoothened, stem cell maintenance and brain diseases -- Medulloblastoma, pediatric brain tumors and Smoothened blockade -- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization -- Implications in stem cell maintenance -- Comparison of the crystal structure of Smoothened to known GPCRs structure.
520 $a Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series topics in medicinal chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
650 0 $a Regenerative medicine $x Methods. $3 2156338
650 0 $a Regenerative medicine $x Cancer. $3 2156339
650 1 4 $a Chemistry. $3 516420
650 2 4 $a Medicinal Chemistry. $3 892420
650 2 4 $a Receptors. $3 1000988
650 2 4 $a Cancer Research. $3 891172
700 1 $a Ruat, Martial. $3 2156337
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer eBooks
830 0 $a Topics in medicinal chemistry ; $v 8 $3 1959760
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-19755-5
950 $a Chemistry and Materials Science (Springer-11644)