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Evaluation of drug candidates for preclinical development = pharmacokinetics, metabolism, pharmaceutics, and toxicology /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Evaluation of drug candidates for preclinical development/ [edited by] Chao Han, Charles B. Davis, Binghe Wang.
Reminder of title:	pharmacokinetics, metabolism, pharmaceutics, and toxicology /
other author:	Han, Chao.
Published:	Hoboken, N.J. :John Wiley & Sons, : c2010.,
Description:	1 online resource.
Notes:	Wiley online library (ebook collection)
[NT 15003449]:	Pharmacokinetics in preclinical drug development : an overview / Dion Brocks -- The role of membrane transporters in drug disposition / Fanfan Zhou, Peng Duan, and Guofeng You -- Cytochrome P450 : structure, function, and application in drug discovery and development / Ramesh B. Bambal and Stephen E. Clarke -- The role of drug metabolism and metabolite identification in drug discovery / Xiangming Guan -- Protein binding in drug discovery and development / Vikram Ramanathan and Nimish Vachharajani -- Prediction of the pharmacokinetics in humans / Chao Han and Remash Bambal -- Pharmaceutics developability assessment / Lian Huang, Jinquan Dong, and Shyam Karki -- Safety assessment in drug discovery / Vito G. Sasseville, William R. Foster, Bruce D. Car -- Assessment of strategies utilized to minimize the potential for induction of acquired long QT syndrome and torsade de pointes / Khuram W. Chaudhary and Barry S. Brown.
Subject:	Pharmacology - methods. -
Online resource:	http://dx.doi.org/10.1002/9780470574898
ISBN:	9780470574898

Evaluation of drug candidates for preclinical development = pharmacokinetics, metabolism, pharmaceutics, and toxicology /
Evaluation of drug candidates for preclinical developmentpharmacokinetics, metabolism, pharmaceutics, and toxicology /[electronic resource] :[edited by] Chao Han, Charles B. Davis, Binghe Wang. - Hoboken, N.J. :John Wiley & Sons,c2010. - 1 online resource. - Wiley series in drug discovery and development. - Wiley series in drug discovery and development..

Wiley online library (ebook collection)

Includes bibliographical references and index.

Pharmacokinetics in preclinical drug development : an overview / Dion Brocks -- The role of membrane transporters in drug disposition / Fanfan Zhou, Peng Duan, and Guofeng You -- Cytochrome P450 : structure, function, and application in drug discovery and development / Ramesh B. Bambal and Stephen E. Clarke -- The role of drug metabolism and metabolite identification in drug discovery / Xiangming Guan -- Protein binding in drug discovery and development / Vikram Ramanathan and Nimish Vachharajani -- Prediction of the pharmacokinetics in humans / Chao Han and Remash Bambal -- Pharmaceutics developability assessment / Lian Huang, Jinquan Dong, and Shyam Karki -- Safety assessment in drug discovery / Vito G. Sasseville, William R. Foster, Bruce D. Car -- Assessment of strategies utilized to minimize the potential for induction of acquired long QT syndrome and torsade de pointes / Khuram W. Chaudhary and Barry S. Brown.

Explaining the assessment of potential drug compounds, this is an ideal introductory reference for those new to drug discovery. It includes sections on pharmacokinetics and drug metabolism, integration of pharmaceutical development, and predictive safety assessment. Topics include: cost analysis, drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, assessing stability, ways to optimize drug formulation, toxicology and toxicokinetics, and more. Readers will understand why absorption-distribution-metabolism-excretion-toxicology (ADMET) is key in drug developmen.

ISBN: 9780470574898

Standard No.: 10.1002/9780470574898doi

Source: 10.1002/9780470574898Wiley InterSciencehttp://www3.interscience.wiley.comSubjects--Topical Terms:

773559
Pharmacology
--methods.

LC Class. No.: RM301.25 / .E93 2010

Dewey Class. No.: 615/.19

National Library of Medicine Call No.: QV 771 / E917 2010

Evaluation of drug candidates for preclinical development = pharmacokinetics, metabolism, pharmaceutics, and toxicology /
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504 $a Includes bibliographical references and index.
505 0 $a Pharmacokinetics in preclinical drug development : an overview / Dion Brocks -- The role of membrane transporters in drug disposition / Fanfan Zhou, Peng Duan, and Guofeng You -- Cytochrome P450 : structure, function, and application in drug discovery and development / Ramesh B. Bambal and Stephen E. Clarke -- The role of drug metabolism and metabolite identification in drug discovery / Xiangming Guan -- Protein binding in drug discovery and development / Vikram Ramanathan and Nimish Vachharajani -- Prediction of the pharmacokinetics in humans / Chao Han and Remash Bambal -- Pharmaceutics developability assessment / Lian Huang, Jinquan Dong, and Shyam Karki -- Safety assessment in drug discovery / Vito G. Sasseville, William R. Foster, Bruce D. Car -- Assessment of strategies utilized to minimize the potential for induction of acquired long QT syndrome and torsade de pointes / Khuram W. Chaudhary and Barry S. Brown.
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