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An optical density detection platfor...

Mosteller, Matthew Philip.

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An optical density detection platform with integrated microfluidics for in situ growth, monitoring, and treatment of bacterial biofilms.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	An optical density detection platform with integrated microfluidics for in situ growth, monitoring, and treatment of bacterial biofilms./
Author:	Mosteller, Matthew Philip.
Description:	184 p.
Notes:	Source: Masters Abstracts International, Volume: 51-05.
Contained By:	Masters Abstracts International51-05(E).
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1535570
ISBN:	9781303016097

An optical density detection platform with integrated microfluidics for in situ growth, monitoring, and treatment of bacterial biofilms.
Mosteller, Matthew Philip.

An optical density detection platform with integrated microfluidics for in situ growth, monitoring, and treatment of bacterial biofilms. - 184 p.

Source: Masters Abstracts International, Volume: 51-05.

Thesis (M.S.)--University of Maryland, College Park, 2012.

Systems engineering strategies utilizing platform-based design methodologies are implemented to achieve the integration of biological and physical system components in a biomedical system. An application of this platform explored, in which an integrated microsystem is developed capable of the on-chip growth, monitoring, and treatment of bacterial biofilms for drug development and fundamental study applications. In this work, the developed systems engineering paradigm is utilized to develop a device system implementing linear array charge-coupled devices to enable real time, non-invasive, label-free monitoring of bacterial biofilms. A novel biofilm treatment method is demonstrated within the developed microsystem showing drastic increases in treatment efficacy by decreasing both bacterial biomass and cell viability within treated biofilms. Demonstration of this treatment at the microscale enables future applications of this method for the in vivo treatment of biofilm-associated infections.

ISBN: 9781303016097Subjects--Topical Terms:

1017684
Engineering, Biomedical.

An optical density detection platform with integrated microfluidics for in situ growth, monitoring, and treatment of bacterial biofilms.
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020 $a 9781303016097
035 $a (MiAaPQ)AAI1535570
035 $a AAI1535570
040 $a MiAaPQ $c MiAaPQ
100 1 $a Mosteller, Matthew Philip. $3 2105996
245 1 3 $a An optical density detection platform with integrated microfluidics for in situ growth, monitoring, and treatment of bacterial biofilms.
300 $a 184 p.
500 $a Source: Masters Abstracts International, Volume: 51-05.
500 $a Adviser: Reza Ghodssi.
502 $a Thesis (M.S.)--University of Maryland, College Park, 2012.
520 $a Systems engineering strategies utilizing platform-based design methodologies are implemented to achieve the integration of biological and physical system components in a biomedical system. An application of this platform explored, in which an integrated microsystem is developed capable of the on-chip growth, monitoring, and treatment of bacterial biofilms for drug development and fundamental study applications. In this work, the developed systems engineering paradigm is utilized to develop a device system implementing linear array charge-coupled devices to enable real time, non-invasive, label-free monitoring of bacterial biofilms. A novel biofilm treatment method is demonstrated within the developed microsystem showing drastic increases in treatment efficacy by decreasing both bacterial biomass and cell viability within treated biofilms. Demonstration of this treatment at the microscale enables future applications of this method for the in vivo treatment of biofilm-associated infections.
590 $a School code: 0117.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Electronics and Electrical. $3 626636
650 4 $a Engineering, System Science. $3 1018128
690 $a 0541
690 $a 0544
690 $a 0790
710 2 $a University of Maryland, College Park. $b Systems Engineering. $3 1036274
773 0 $t Masters Abstracts International $g 51-05(E).
790 $a 0117
791 $a M.S.
792 $a 2012
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1535570