東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Spatiotemporal dynamics of protein k...

Violin, Jonathan D.

FindBook

Google Book

Amazon

博客來

Spatiotemporal dynamics of protein kinase C signaling.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Spatiotemporal dynamics of protein kinase C signaling./
作者:	Violin, Jonathan D.
面頁冊數:	166 p.
附註:	Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2613.
Contained By:	Dissertation Abstracts International64-06B.
標題:	Health Sciences, Pharmacology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3094617

Spatiotemporal dynamics of protein kinase C signaling.
Violin, Jonathan D.

Spatiotemporal dynamics of protein kinase C signaling. - 166 p.

Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2613.

Thesis (Ph.D.)--University of California, San Diego, 2003.

Despite many advances in contemporary pharmacology and cell biology, there still exists an epistemological chasm between data gathered biochemically and data gathered from whole animal or tissue. In complex systems of signal transduction, such as for Protein Kinase C (PKC), the lack of precise information at the cellular level can preclude meaningful integration of biochemical and animal data into comprehensive understanding of a signaling system. This dissertation extends knowledge gained from previous PKC research to live cell experiments using technologies based upon <italic>A. Victoria</italic> Green Fluorescent Protein. Specifically, this dissertation shows that genetically encoded fluorescent reporters for PKC conformational changes, lipid raft microdomains, and PKC substrate phosphorylation provide molecular detail to PKC function in living cells. The results presented here show a remarkable fidelity of PKC signal transduction to dynamic regulation, and suggest that such methods may be applicable to a wide variety of kinase signals in living cells. We describe PKC as a signal integrator that allows cells to process rapidly changing environmental cues with high temporal precision, providing cells with a mechanism for high-content information in the form of dynamic phosphorylation.Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Spatiotemporal dynamics of protein kinase C signaling.
LDR:02183nmm 2200277 4500 001 1859374
005 20041014084349.5
008 130614s2003 eng d
035 $a (UnM)AAI3094617
035 $a AAI3094617
040 $a UnM $c UnM
100 1 $a Violin, Jonathan D. $3 1947034
245 1 0 $a Spatiotemporal dynamics of protein kinase C signaling.
300 $a 166 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2613.
500 $a Chair: Alexandra C. Newton.
502 $a Thesis (Ph.D.)--University of California, San Diego, 2003.
520 $a Despite many advances in contemporary pharmacology and cell biology, there still exists an epistemological chasm between data gathered biochemically and data gathered from whole animal or tissue. In complex systems of signal transduction, such as for Protein Kinase C (PKC), the lack of precise information at the cellular level can preclude meaningful integration of biochemical and animal data into comprehensive understanding of a signaling system. This dissertation extends knowledge gained from previous PKC research to live cell experiments using technologies based upon <italic>A. Victoria</italic> Green Fluorescent Protein. Specifically, this dissertation shows that genetically encoded fluorescent reporters for PKC conformational changes, lipid raft microdomains, and PKC substrate phosphorylation provide molecular detail to PKC function in living cells. The results presented here show a remarkable fidelity of PKC signal transduction to dynamic regulation, and suggest that such methods may be applicable to a wide variety of kinase signals in living cells. We describe PKC as a signal integrator that allows cells to process rapidly changing environmental cues with high temporal precision, providing cells with a mechanism for high-content information in the form of dynamic phosphorylation.
590 $a School code: 0033.
650 4 $a Health Sciences, Pharmacology. $3 1017717
650 4 $a Biology, Cell. $3 1017686
650 4 $a Biology, Molecular. $3 1017719
690 $a 0419
690 $a 0379
690 $a 0307
710 2 0 $a University of California, San Diego. $3 1018093
773 0 $t Dissertation Abstracts International $g 64-06B.
790 1 0 $a Newton, Alexandra C., $e advisor
790 $a 0033
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3094617