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Bioinformatic and molecular characte...

Lee, Ji Young.

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Bioinformatic and molecular characterization of the LrrCAM superfamily in Caenorhabditis elegans.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Bioinformatic and molecular characterization of the LrrCAM superfamily in Caenorhabditis elegans./
作者:	Lee, Ji Young.
面頁冊數:	570 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6195.
Contained By:	Dissertation Abstracts International65-12B.
標題:	Biology, Molecular. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3155637
ISBN:	0496163590

Bioinformatic and molecular characterization of the LrrCAM superfamily in Caenorhabditis elegans.
Lee, Ji Young.

Bioinformatic and molecular characterization of the LrrCAM superfamily in Caenorhabditis elegans. - 570 p.

Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6195.

Thesis (Ph.D.)--The Johns Hopkins University, 2005.

Leucine-rich repeats (LRRs) are short, amino-terminal sequence motifs that characterize a superfamily of proteins. Although the individual members of this protein family vary in function and cellular localization, most seem to be involved in protein-protein interactions. Caenorhabditis elegans possess 21 genes that appear to encode presumptive cell surface proteins containing an extracellular amino-terminal LRR domain. These proteins are labeled LRR-1 to LRR-21. We uncovered an additional candidate, Y37E3.13. Some of these are apparent orthologues of molecules implicated in activities such as neuronal development. However, the functional significance and expression patterns for most of the predicted LRR gene products have not yet been determined.

ISBN: 0496163590Subjects--Topical Terms:

1017719
Biology, Molecular.

Bioinformatic and molecular characterization of the LrrCAM superfamily in Caenorhabditis elegans.
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245 1 0 $a Bioinformatic and molecular characterization of the LrrCAM superfamily in Caenorhabditis elegans.
300 $a 570 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6195.
500 $a Adviser: Edward Hedgecock.
502 $a Thesis (Ph.D.)--The Johns Hopkins University, 2005.
520 $a Leucine-rich repeats (LRRs) are short, amino-terminal sequence motifs that characterize a superfamily of proteins. Although the individual members of this protein family vary in function and cellular localization, most seem to be involved in protein-protein interactions. Caenorhabditis elegans possess 21 genes that appear to encode presumptive cell surface proteins containing an extracellular amino-terminal LRR domain. These proteins are labeled LRR-1 to LRR-21. We uncovered an additional candidate, Y37E3.13. Some of these are apparent orthologues of molecules implicated in activities such as neuronal development. However, the functional significance and expression patterns for most of the predicted LRR gene products have not yet been determined.
520 $a We are interested in intercellular signaling, specifically as it relates to synaptic patterning. The LRR superfamily is a good candidate for instructive factors in this process. Furthermore, the simple multicellular architecture of the C. elegans nematode provides an ideal context in which to designate roles for the putative LRR gene products and, additionally, to characterize the apparent orthologues more completely. The bioinformatic and molecular analyses of the LRR superfamily members presented in this work provides the foundation upon to which assess their potential synaptic patterning roles.
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