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A genetic study of inebriated, a Dro...

Huang, Yanmei.

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A genetic study of inebriated, a Drosophila gene that physical dual roles in the control of neuronal excitability and the osmotic stress response.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	A genetic study of inebriated, a Drosophila gene that physical dual roles in the control of neuronal excitability and the osmotic stress response./
作者:	Huang, Yanmei.
面頁冊數:	134 p.
附註:	Adviser: Michael Stern.
Contained By:	Dissertation Abstracts International63-03B.
標題:	Biology, Genetics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3047316
ISBN:	049361527X

A genetic study of inebriated, a Drosophila gene that physical dual roles in the control of neuronal excitability and the osmotic stress response.
Huang, Yanmei.

A genetic study of inebriated, a Drosophila gene that physical dual roles in the control of neuronal excitability and the osmotic stress response. - 134 p.

Adviser: Michael Stern.

Thesis (Ph.D.)--Rice University, 2002.

The <italic>Drosophila inebriated</italic> (<italic>ine</italic>) gene encodes a putative transporter (Ine) that shares high homology to members of the Na<super>+</super>/Cl<super>−</super> dependent neurotransmitter transporter family. Mutations in the <italic>ine</italic> gene were found to cause increased neuronal excitability. Research documented in this thesis demonstrated that <italic>ine</italic> also confers defective osmotic stress response, confirming the dual roles played by certain members of this family in regulating both neuronal excitability and osmotic stress response. In addition, from further investigation of the neuronal phenotypes of <italic>ine</italic> mutants it was discovered that Ine might act in short-term to affect neuronal excitability, that the transporter can exert its function from either neurons or glia, and that the two isoforms of the transporter, Ine-P1 and Ine-P2, which are identical in major portion of their sequence but differ in their N termini, are both capable of their function in the absence of the other, although the former functions more efficiently. Furthermore, <italic>ine</italic> overexpression causes phenotypes that closely resemble those of mutants with defective sodium channels. These phenotypes include delayed onset of long-term facilitation, suppression of the leg-shaking phenotypes of <italic>Shaker </italic>, temperature sensitive paralysis, enhancement of the <italic>paralytic </italic> (<italic>para</italic>) mutation, increased failure rate of transmitter release at the larval neuromuscular junction, reduced amplitude of larval nerve compound action potential and failure of compound action potential at restrictive temperature. Taken together, these observations raise the possibility that <italic>ine</italic> might be involved in a signaling pathway that regulates neuronal sodium channels.

ISBN: 049361527XSubjects--Topical Terms:

1017730
Biology, Genetics.

A genetic study of inebriated, a Drosophila gene that physical dual roles in the control of neuronal excitability and the osmotic stress response.
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