東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回上頁

切換: 標籤 | MARC模式 | ISBD

The glutamate/GABA-glutamine cycle =...

Schousboe, Arne.

FindBook

Google Book

Amazon

博客來

The glutamate/GABA-glutamine cycle = amino acid neurotransmitter homeostasis /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The glutamate/GABA-glutamine cycle/ edited by Arne Schousboe, Ursula Sonnewald.
其他題名:	amino acid neurotransmitter homeostasis /
其他作者:	Schousboe, Arne.
出版者:	Cham :Springer International Publishing : : 2016.,
面頁冊數:	x, 416 p. :ill., digital ;24 cm.
內容註:	Introduction to the Glutamate-Glutamine cycle -- Glucose, lactate, β-hydroxybutyrate, acetate, GABA, and succinate as substrates for synthesis of glutamate and GABA in the glutamine-glutamate/GABA cycle -- Anaplerosis for glutamate synthesis in the neonate and in adulthood -- Enzyme complexes important for the glutamate-glutamine cycle -- BCAA metabolism and NH3 homeostasis -- Glutaminases Vesicular Glutamate Uptake -- The glutamine transporters and their role in the Glutamate/GABA-Glutamine Cycle -- Glutamine Metabolism in Gliomas -- Oligodendrocytes: development, physiology and glucose metabolism -- Dysregulation of glutamate cycling mediates methylmercury-induced neurotoxicity -- Astroglia, glutamatergic transmission and psychiatric diseases -- Glutamine Synthetase: Role in Neurological Disorders -- The Glutamate - Glutamine Cycle in Epilepsy -- Index.
Contained By:	Springer eBooks
標題:	Glutamic acid. -
電子資源:	http://dx.doi.org/10.1007/978-3-319-45096-4
ISBN:	9783319450964

The glutamate/GABA-glutamine cycle = amino acid neurotransmitter homeostasis /
The glutamate/GABA-glutamine cycleamino acid neurotransmitter homeostasis /[electronic resource] :edited by Arne Schousboe, Ursula Sonnewald. - Cham :Springer International Publishing :2016. - x, 416 p. :ill., digital ;24 cm. - Advances in neurobiology,v.132190-5215 ;. - Advances in neurobiology ;v.13..

Introduction to the Glutamate-Glutamine cycle -- Glucose, lactate, β-hydroxybutyrate, acetate, GABA, and succinate as substrates for synthesis of glutamate and GABA in the glutamine-glutamate/GABA cycle -- Anaplerosis for glutamate synthesis in the neonate and in adulthood -- Enzyme complexes important for the glutamate-glutamine cycle -- BCAA metabolism and NH3 homeostasis -- Glutaminases Vesicular Glutamate Uptake -- The glutamine transporters and their role in the Glutamate/GABA-Glutamine Cycle -- Glutamine Metabolism in Gliomas -- Oligodendrocytes: development, physiology and glucose metabolism -- Dysregulation of glutamate cycling mediates methylmercury-induced neurotoxicity -- Astroglia, glutamatergic transmission and psychiatric diseases -- Glutamine Synthetase: Role in Neurological Disorders -- The Glutamate - Glutamine Cycle in Epilepsy -- Index.

Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term "The Glutamate-Glutamine Cycle." In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction.

ISBN: 9783319450964

Standard No.: 10.1007/978-3-319-45096-4doiSubjects--Topical Terms:

898725
Glutamic acid.

LC Class. No.: QP562.G5

Dewey Class. No.: 612.01575

The glutamate/GABA-glutamine cycle = amino acid neurotransmitter homeostasis /
LDR:03649nmm a2200325 a 4500 001 2080514
003 DE-He213
005 20161125003335.0
006 m d
007 cr nn 008maaau
008 170616s2016 gw s 0 eng d
020 $a 9783319450964 $q (electronic bk.)
020 $a 9783319450940 $q (paper)
024 7 $a 10.1007/978-3-319-45096-4 $2 doi
035 $a 978-3-319-45096-4
040 $a GP $c GP
041 0 $a eng
050 4 $a QP562.G5
072 7 $a PSAN $2 bicssc
072 7 $a MED057000 $2 bisacsh
082 0 4 $a 612.01575 $2 23
090 $a QP562.G5 $b G567 2016
245 0 4 $a The glutamate/GABA-glutamine cycle $h [electronic resource] : $b amino acid neurotransmitter homeostasis / $c edited by Arne Schousboe, Ursula Sonnewald.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2016.
300 $a x, 416 p. : $b ill., digital ; $c 24 cm.
490 1 $a Advances in neurobiology, $x 2190-5215 ; $v v.13
505 0 $a Introduction to the Glutamate-Glutamine cycle -- Glucose, lactate, β-hydroxybutyrate, acetate, GABA, and succinate as substrates for synthesis of glutamate and GABA in the glutamine-glutamate/GABA cycle -- Anaplerosis for glutamate synthesis in the neonate and in adulthood -- Enzyme complexes important for the glutamate-glutamine cycle -- BCAA metabolism and NH3 homeostasis -- Glutaminases Vesicular Glutamate Uptake -- The glutamine transporters and their role in the Glutamate/GABA-Glutamine Cycle -- Glutamine Metabolism in Gliomas -- Oligodendrocytes: development, physiology and glucose metabolism -- Dysregulation of glutamate cycling mediates methylmercury-induced neurotoxicity -- Astroglia, glutamatergic transmission and psychiatric diseases -- Glutamine Synthetase: Role in Neurological Disorders -- The Glutamate - Glutamine Cycle in Epilepsy -- Index.
520 $a Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term "The Glutamate-Glutamine Cycle." In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction.
650 0 $a Glutamic acid. $3 898725
650 0 $a Neurotransmitters. $3 590664
650 1 4 $a Biomedicine. $3 890831
650 2 4 $a Neurosciences. $3 588700
700 1 $a Schousboe, Arne. $3 916905
700 1 $a Sonnewald, Ursula. $3 3200471
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer eBooks
830 0 $a Advances in neurobiology ; $v v.13. $3 3200472
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-45096-4
950 $a Biomedical and Life Sciences (Springer-11642)