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Dna-encoded libraries

Brunschweiger, Andreas.

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Dna-encoded libraries

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Dna-encoded libraries/ edited by Andreas Brunschweiger, Damian W. Young ; with contributions by M. J. Anderson ... [et al.].
其他作者:	Brunschweiger, Andreas.
出版者:	Cham :Springer International Publishing : : 2022.,
面頁冊數:	ix, 276 p. :ill., digital ;24 cm.
內容註:	A History of Selection-Based High-Throughput Screening Technologies for Hit Identification -- Barcoding Strategies for the Synthesis of Genetically Encoded Chemical Libraries -- Advancements in DEL-Compatible Chemical Reactions -- Design Considerations in Constructing and Screening DNA-Encoded Libraries -- Cheminformatics Approaches Aiding the Design and Selection of DNA-Encoded Libraries -- Selection Strategies in DNA-Encoded Libraries -- From DEL Selections to Validated Hits to Clinical Leads -- A Perspective on 30 Years of DNA-Encoded Chemistry.
Contained By:	Springer Nature eBook
標題:	Combinatorial chemistry. -
電子資源:	https://doi.org/10.1007/978-3-031-18629-5
ISBN:	9783031186295

Dna-encoded libraries
Dna-encoded libraries[electronic resource] /edited by Andreas Brunschweiger, Damian W. Young ; with contributions by M. J. Anderson ... [et al.]. - Cham :Springer International Publishing :2022. - ix, 276 p. :ill., digital ;24 cm. - Topics in medicinal chemistry,v. 401862-247X ;. - Topics in medicinal chemistry ;v. 40..

A History of Selection-Based High-Throughput Screening Technologies for Hit Identification -- Barcoding Strategies for the Synthesis of Genetically Encoded Chemical Libraries -- Advancements in DEL-Compatible Chemical Reactions -- Design Considerations in Constructing and Screening DNA-Encoded Libraries -- Cheminformatics Approaches Aiding the Design and Selection of DNA-Encoded Libraries -- Selection Strategies in DNA-Encoded Libraries -- From DEL Selections to Validated Hits to Clinical Leads -- A Perspective on 30 Years of DNA-Encoded Chemistry.

This book deals with the recent advances in DNA-Encoded Library (DEL) technology that has emerged as an alternative to high throughput screening(HTS) over the last decade and has been heralded as a "disruptive" technology for drug discovery. The book aims to provide a comprehensive overview of all of the major components of the DEL process from conception to bench execution and clinical investigations. The contributions from experts in the field combine different perspectives from academia and industry. The book will be of interest to researchers in the drug discovery field as well as graduate students and scholars who are interested in this rapidly improving technology.

ISBN: 9783031186295

Standard No.: 10.1007/978-3-031-18629-5doiSubjects--Topical Terms:

605680
Combinatorial chemistry.

LC Class. No.: RS419

Dewey Class. No.: 615.19

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520 $a This book deals with the recent advances in DNA-Encoded Library (DEL) technology that has emerged as an alternative to high throughput screening(HTS) over the last decade and has been heralded as a "disruptive" technology for drug discovery. The book aims to provide a comprehensive overview of all of the major components of the DEL process from conception to bench execution and clinical investigations. The contributions from experts in the field combine different perspectives from academia and industry. The book will be of interest to researchers in the drug discovery field as well as graduate students and scholars who are interested in this rapidly improving technology.
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